Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer
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چکیده
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Molecular cloning and expression analysis of evolutionarily conserved stathmin from Gekko japonicus spinal cord.
The cDNA encoding stathmin is identified from the brain and spinal cord cDNA library of Gekko japonicus. It contains a 450 bp open-reading-frame, corresponding to a deduced protein of 149 amino acids. At amino acid level. gecko stathmin shares more than 76.4% identities with vertebrate stathmins, and especially, it shares 100% identity with human stathmin, suggesting that the selective pressure...
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Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental for biology and medicine. Here we undertook a genome-wide comparative genomics approach using available mammalian genomes to identify conserved intronic splicing regulatory elements (ISREs). Our approach yielded 314 ISREs, and insertions of ~70 ISREs between competing ...
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ژورنال
عنوان ژورنال: Development
سال: 2010
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.043257